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The collaborative Human Challenge study is the first in the world to perform detailed monitoring over the full course of COVID-19, from the moment a person first encounters SARS-CoV-2, throughout the infection to the point at which the virus is apparently eliminated. The Human Challenge Programme is a partnership between Imperial College London, the Vaccine Taskforce and Department of Health and Social Care (DHSC), hVIVO (part of Open Orphan plc.), and the Royal Free London NHS Foundation Trust.

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How deliberately giving people illnesses is supercharging medicine

The covid-19 pandemic opened the door to once-controversial human challenge trials. Now, volunteers are willingly catching norovirus and influenza to reveal how our immune systems really fight back

Features

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Hepatitis B vaccine linked with a lower risk of developing diabetes

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Will an mRNA vaccine target the norovirus strain behind surging cases?

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Flu vaccine for children linked to pneumonia risk for their relatives

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Peter Hotez, founding dean and chief of the Baylor College of Medicine National School of Tropical Medicine, speaks during a House Science, Space and Technology Committee hearing on Capitol Hill in Washington, D.C., U.S., on Thursday, March 5, 2020. The Trump administration won't be able to meet its promised timeline of having a million coronavirus tests available by the end of the week, senators said after a briefing from health officials. Photographer: Sarah Silbiger/Bloomberg via Getty Images

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The Deadly Rise of Anti-science review: The personal cost of research

Culture

People with dengue in hospital in Dhaka, Bangladesh, in July

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Why is it so difficult to make an effective vaccine against dengue?

Analysis

A Moderna research associate pictured in a laboratory at the company's Cambridge, Massachusetts, headquarters

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Personalised melanoma vaccines prolong survival in largest trial yet

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A pregnant person receives the Pfizer/BioNTech vaccine against covid-19 in Schwenksville, Pennsylvania in February 2021

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Covid-19 vaccines in pregnancy not linked to miscarriage or stillbirth

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People queue at a monkeypox vaccination site in Encino, LA in California, in July

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Vaccinating less than half of high-risk men may stop monkeypox spread

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Bronchiolitis is most commonly caused by the respiratory syncytial virus (RSV)

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RSV vaccine that may protect against bronchiolitis has promise in mice

An experimental vaccine warded off the respiratory syncytial virus, the most common cause of the chest infection bronchiolitis, in newborn mice

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Covid-19 vaccines may ward off long covid even if given post-infection

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Vaccine may protect against the virus behind multiple sclerosis

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mRNA vaccine against tick bites could help prevent Lyme disease

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Health

Skin patch coated in covid-19 vaccine may work better than injections

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