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Nasal spray could buy time in flu pandemic

Efforts to develop a universal flu vaccine may have stalled, but the research has revealed an antibody that protects against several lethal flu strains

A better defence against pandemic flu may be on the way.

It takes months to make a flu vaccine but, as each vaccine works against only one particular flu virus, we can’t stockpile any.

In 2011, researchers looking for a universal vaccine found an antibody that attacks all flu viruses. Normally flu tricks us into making too little of the antibody to make a difference, but James Wilson at the University of Pennsylvania, Philadelphia, and his team have created a workaround.

They put the DNA that codes for the antibody into an innocuous virus and squirted it into the noses of mice and ferrets. There it made the antibody, which protected the animals against flu viruses including the lethal H5N1 bird flu.

Such a stockpiled remedy could buy time in a pandemic while a vaccine is made, the team say.

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Topics: Epidemics / Flu / pandemics