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Health

Our guts may sense sugar and low-calorie sweeteners differently

By Jessica Hamzelou

19 March 2020

woman holding sugar cubes and saccharin pills

The gut can distinguish sugar from low-calorie alternatives

Antonio Guillem/Getty Images

Can you taste the difference between a calorie-laden sugar and a zero-calorie sweetener? Specialised cells in your gut can, according to experiments in mice. These cells tell the brain whether a sugar or sweetener has been ingested within milliseconds.

revealed that food doesn’t need to pass through the mouth to stimulate a response from the brain. Mice respond to food rewards when they are put directly into their stomachs, too. More recent studies have found that

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