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Health

CRISPR gene editing of brain cells might prevent Alzheimer's disease

By Michael Le Page

26 November 2020

Amyloid plaques in Alzheimer's disease

Artist’s impression of amyloid plaques in a brain with Alzheimer’s disease

nobeastsofierce/Science Photo Library

It might one day be possible to gene-edit brain cells to prevent Alzheimer’s disease. Researchers have discovered that altering a key gene in human nerve cells reduces the formation of a protein associated with the disease, though so far this has only been done in a dish.

Alzheimer’s is the main cause of dementia and the risk rises sharply as we grow old. Around 1 in 4 people aged over 90 have it.

The cause of Alzheimer’s still isn’t fully understood, but the leading hypothesis…

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