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Genetically engineered bacteria have learned to play tic-tac-toe

E. coli bacteria modified to act like electronic components called memristors can be set up to act as a simple neural network and trained to play noughts and crosses

By Michael Le Page

13 May 2022

ΒιΆΉ΄«Γ½. Science news and long reads from expert journalists, covering developments in science, technology, health and the environment on the website and the magazine.

Wells of bacteria representing a tic-tac-toe grid

Alfonso Jaramillo/CSIC

For the first time, humans have played tic-tac-toe – also known as noughts and crosses – with bacteria. These were no ordinary bacteria, but E. coli extensively genetically modified and set up to act as a simple neural network, a form of artificial intelligence.

This approach could have all kinds of applications, from creating living materials capable of learning to making β€œsmart” microbiomes, says at the Spanish National Research Council.

He and his team started with an E. coli strain genetically modified to sense 12 different chemicals and respond…

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