Âé¶¹´«Ã½

On-off switch for HIV

By Cristina Serra

26 May 2001

A STRAIN of HIV that can only replicate in the presence of a specific drug
has been developed by researchers in the Netherlands. They say the virus could
be the basis for a safe live HIV vaccine.

Many vaccines are based on weakened viruses that can replicate and provoke an
immune response, but don’t cause disease. But so far HIV has defeated all
efforts to create such a “live attenuated vaccine”. Whenever researchers weaken
the virus by deleting or altering its genes, it mutates and reverts back to a
dangerous form.

So Giuseppe Marzio and his colleagues at the University…

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