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Decoding the Ys and wherefores of males

By Sylvia Pagán Westphal

21 June 2003

THE genetic sequence of the human Y chromosome has been published, unveiling surprises that will advance research on fertility, rekindle debates on the evolution of the sexes and challenge the controversial idea that the Y chromosome is a genetic junkyard destined for extinction.

The male-determining Y has been considered a vestigial chromosome with a tiny, ever-dwindling collection of about 40 genes. The reason for the genetic attrition, scientists thought, was Y’s inability to pair and swap genetic material with other chromosomes. That takes place during a process called crossing-over, which is key to repairing genetic mutations and preserving genes.

Because…

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