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Rare mutation sends lung cancer risk through the roof

7 August 2004

People who smoke even a little have a dramatically increased risk of lung cancer if they carry a rare version of a small piece of chromosome 6.

A handful of genes have been found that can slightly alter the risk of lung cancer, but a few studies have suggested that rare mutations in some genes could boost the risk of the cancer 14 times.

After a 20-year hunt, human geneticist Joan Bailey-Wilson at the National Human Genome Research Institute near Washington DC and her colleagues believe they have narrowed down the search for one or more of these “major lung…

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