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Health

TB vaccine ain't what it used to be

By Debora Mackenzie

14 March 2007

TUBERCULOSIS kills nearly 2 million people every year. The existing vaccine, known as BCG, does not work that well, and no new vaccines are imminent. Yet we may already have a much better one sitting on the shelf: vintage BCG.

BCG is a live, weakened strain of Mycobacterium tuberculosis, the bacterium that causes TB. It is still given in some developing countries, where meningitis caused by M. tuberculosis is a threat to children. But BCG has fallen out of favour for preventing the most common form of TB in the lungs. It often gives little protection, mainly because people’s…

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