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Life

Longevity gene keeps the brain ticking over

By Andy Coghlan

11 June 2008

Âé¶¹´«Ã½. Science news and long reads from expert journalists, covering developments in science, technology, health and the environment on the website and the magazine.

A GENE linked to IQ might also help to prolong life.

The gene codes for an enzyme called succinic semialdehyde dehydrogenase (SSADH), which destroys GABA, a neurotransmitter that dampens brain activity and causes drowsiness. The gene comes in two common forms: the so-called “T” version is 20 per cent less efficient than the “C” version. In previous studies, young people with two copies of the T version performed slightly worse on IQ tests.

SSADH also detoxifies the brain by getting rid of excess acid, helping to protect cells from the free-radical damage that accelerates ageing.

So to study the effects…

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