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Alcohol during pregnancy chemically alters fetal DNA

20 January 2010

DRINKING too much while pregnant chemically alters the fetus’s DNA and changes gene activity, a study in mice suggests.

When a pregnant woman drinks excessively, fetal alcohol syndrome can do permanent damage to her child. Suyinn Chong at the Queensland Institute of Medical Research in Herston, Australia, wondered whether “epigenetic” chemical changes to DNA – changes not in the genetic code itself but in the activity of certain genes – might be to blame.

Chong’s team bred mice with genes for brown and yellow fur that are known to be modified by epigenetics. The offspring of mothers that drank alcohol were brown more often than you would expect…

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