MICE with a “human” liver could be used to study malaria, hepatitis and cirrhosis.
of the Salk Institute in La Jolla, California, and colleagues created mice that lacked a range of immune cells and a toxin-clearing enzyme, which meant that their liver cells died unless they were given a drug.
Then the team injected the mice with human liver cells and withdrew the drug. These cells homed in on the mouse livers, where they replaced dying mouse cells (The Journal of Clinical Investigation, ). The livers appeared to act like human ones, producing human, not mouse,…
