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Letter: Is this why bioscience has a replication issue?

Published 20 April 2022

From Dave Smith,Alnwick, Northumberland, UK

While the points made in “Failure to replicate” are all reasonable, there is a potentially valuable explanation for seemingly unreproducible experiments: an additional factor that hasn’t been controlled for (9 April, p 45).

For example, when researchers were faced with different results from genetically identical mice obtained from different suppliers, patient detective work led them to a . Interestingly, not only is the microbiome of people very variable, but so, too, is

Issue no. 3383 published 23 April 2022

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