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Letter: An explanation for the honest placebo effect

Published 28 May 2025

From Susan Eckenwalder, Toronto, Canada

Since the effects of an illness are easily compounded by the psychosomatic pain of thinking it is worse than it actually is, there may be a reasonable explanation for finding that a placebo works even if you know you are taking it. Maybe just knowing a doctor thinks you are well enough to take a placebo rather than “real medicine” is enough to convince you that you are indeed better than you thought, thus reducing your stress-induced pain(5 April, p 20).

Issue no. 3545 published 31 May 2025

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