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Light micrograph of a section through the spleen of a patient with Gaucher's disease. Small lymphocytes and large macrophage cells (Gaucher?s cells, pink, a type of white blood cell) are present. Gaucher's disease is an inherited metabolic disorder in which a fatty substance called glucocerebroside accumulates in the spleen (in macrophages), lungs, liver and bone marrow, and sometimes the brain. This is due to an absence of the enzyme glucocerebrosidase (GC). The disease appears in childhood, and some forms are fatal in the first few years. Other forms cause enlargement of the affected organs, weak and painful bones and anaemia. Some forms also cause severe nervous system damage. There is no cure, but enzyme replacement therapy using GC can relieve the symptoms. Haematoxylin-eosin saffron (HES) stain. Magnification: x400 at 24x36 mm size.

Health

Genes for Gaucher disease may have protected Jewish people against TB

Gaucher disease, a genetic condition that is more common in Ashkenazi Jewish people, may confer protection against tuberculosis, according to research in zebrafish

News

close up of woman's eyes

Mind

The evolutionary origin of paranoia and why it is becoming more common

Features

Straight-tusked elephant bones hint at routine hunting and butchering by Neanderthals

Humans

Neanderthals hunted enormous elephants that fed 100 people for a month

News

Burying beetle

Life

Animals that care for young may have more mutations and evolve faster

News

Banded mongoose group approaching with curiosity (Mungos mungo). Maasai Mara National Reserve, Kenya. March 2018.

Life

Inside the complex and extremely violent world of warring mongooses

Features

Self-assembled colony formed by wild S. muelleri suspended in solution (see Movie 1) https://doi.org/10.1101/2023.01.10.523506

Life

Multicellular life may have begun with brief alliances between cells

News

Illustratoin of Ignacius dawsonae, a squirrel-like animal in a tree

Life

Early relatives of primates lived in the Arctic 52 million years ago

News

beautiful White-handed Gibbon (Hylobates lar) sitting on ground; Shutterstock ID 569449837; purchase_order: -; job: -; client: -; other: -

Life

Male and female gibbons sing duets in time with each other

News

Finley, one of the sloths at The Sloth Sanctuary in Costa Rica. Credit: Ignacio Moya

Life

Sloths have double the grip strength of humans and other primates

News

Anole lizard on a pole

Life

Urban lizards have gene mutations that help them adapt to city life

Anole lizards living in three cities in Puerto Rico have mutations in genes linked to immune function, limb and skin development, which may help them thrive alongside humans

News

Life

Largest ever animal may have been Triassic ichthyosaur super-predator

Features

Life

Living in trees may have given great apes vocal skills for consonants

News

Life

Fossils reveal the dinosaur era's changing insect soundscape

News

Life

Diversity helped mammals survive asteroid that killed the dinosaurs

News